process for point of use radiosynthesis of PET radiotracers for cancer research
Molecular positron emission tomography (PET) imaging allows study of molecular and cellular processes associated with diseases including cancer. PET in-vivo molecular imaging requires labelling of biomolecules with positron emitting isotopes. These isotopes are short lived, required in small quantities and desirably are synthesised at the point of use. Epigem made microfluidic devices for a group at the Paterson Institute for Cancer Research that enabled them to demonstrate “proof of concept” radiohalogenation of small molecules and biopolymers including iodine-124 labelling of the protein Amexin V. (J.M.Gillies et al, Applied Radiation and Isotopes, 64, (2006), 325-332..